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  • Improvement of physical exercise capacity in patients with Coronary Artery Disease NYHA 2-3
  • Chronic Heart Failure (in research)



  • Acute inflammatory diseases
  • Acute somatic diseases 
  • Congenital heart and major vessels defects
  • Severe chronic obstructive pulmonary disease (COPD)
  • Acute cerebro-vascular events (<6 months prior to IHT)
  • Acute forms of ischaemic heart disease (acute coronary syndrome, myocardial infarction)
  •  Heart failure III-IV clas
  • Chronic obstructive pulmonary disease
  • Bronchial asthma with significant respiratory distress (SpO2 <90%)
  • Renal failure
  • Oncological diseases
  • Systemic diseases
  • Severe psychic diseases
  • Individual intolerance to oxygen defficacy

Physiological effects:

  • Improves the microcirculation [Belyavskiy et al., Bobyleva et al., Ischuk et al., Townsend et al.]
  • Increases myocardium and brain resistance to acute ischaemia (precondition-like effect) [Bulgak et al., Zhua et al.]
  • Reduction in the negative consequences of systemic oxidative stress [Arkhipenko et al., Borukaeva et al., Elchaninova et al.]

Clinical Effects:

  • Increases time to fatigue
  • Increases physical endurance
  • Increases VOpeak
  • Increases %VO2 max
  • Increases Anaerobic threshold
  • Lowers incidence of angina as a reason to stop treadmill run
  • Lowers incidence of ST depression as a reason to stop treadmill run
Eng Effect of hypoxic training on inflammatory and metabolic risk factors: a crossover study in healthy subjects. 2014 Shi B, Watanabe T, Shin S, Yabumoto T, Takemura M, Matsuoka T Physiol Rep.24744877
Eng Hypoxic training: Clinical benefits on cardiometabolic risk factors 2015 Wee J, Climstein M J Sci Med Sport.24268571
Eng Intermittent hypoxia research in the former soviet union and the commonwealth of independent States: history and review of the concept and selected applications. 2002 Serebrovskaya TV High Alt Med Biol. 12162864
Eng Therapeutic potential of intermittent hypoxia: a matter of dose. 2014 Navarrete-Opazo A, Mitchell GS Am J Physiol Regul Integr Comp Physiol25231353
Eng Interval normobaric hypoxic-hyperoxic training increases exercise tolerance in patients with coronary artery disease 2013 Glazachev O, Pozdnyakov Y, Urinskiy A, Dudnik E oral presentation 
Eng Effects of five nights of normobaric hypoxia on the ventilatory responses to acute hypoxia and hypercapnia. 2003 Ainslie PN, Kolb JC, Ide K, Poulin MJ Respir Physiol Neurobiol.14609510
Eng Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes. 2012 Mackenzie R, Maxwell N, Castle P, Elliott B, Brickley G, Watt P. J Clin Endocrinol Metab. 22278428
Eng Normobaric hypoxia conditioning reduces blood pressure and normalizes nitric oxide synthesis in patients with arterial hypertension. 2011 Lyamina NP, Lyamina SV, Senchiknin VN, Mallet RT, Downey HF, Manukhina EB J Hypertens. 21897291
Eng Training in hypoxia: modulation of metabolic and cardiovascular risk factors in men. 2000 Bailey DM, Davies B, Baker J Med Sci Sports Exerc.10862530
Eng The effect of altitude-induced hypoxia on heart disease: do acute, intermittent, and chronic exposures provide cardioprotection? 2011 Anderson JD, Honigman B High Alt Med Biol. 21452965
Eng Effect of prolonged intermittent hypoxia and exercise training on glucose tolerance and muscle GLUT4 protein expression in rats 2004 Chiu LL, Chou SW, Cho YM, Ho HY, Ivy JL, Hunt D, Wang PS, Kuo CH J Biomed Sci.15591781
Eng A hypoxia complement differentiates the muscle response to endurance exercise 2010 Schmutz S, Dapp C, Wittwer M, Durieux AC, Mueller M, Weinstein F, Vogt M, Hoppeler H, Fluck M Exp Physiol 
Eng Intermittent hypoxia conditioning prevents endothelial dysfunction and improves nitric oxide storage in spontaneously hypertensive rats 2008 Manukhina E, Jasti D, Vanin AF, Downey H Experimental Biology and Medicine 
Eng Long-term intermittent hypoxia increases sympathetic activity and chemosensitivity during acute hypoxia in humans 2006 Lusina SJ, Kennedy PM, Inglis JT, McKenzie DC, Ayas NT, Sheel AW J Physiol 
Eng Effects of five consecutive nocturnal hypoxic exposures on the cerebrovascular responses to acute hypoxia and hypercapnia in humans 2004 Kolb JC, Ainslie PN, Ide K, Poulin MJ J Appl Physiol 
Eng Interval hypoxic training improves autonomic cardiovascular and respiratory control in patients with mild chronic obstructive pulmonary disease 2009 Haider T, Casucci G, Linser T, Faulhaber M, Gatterer H, Ott G, Linser A, Erenburg I, Tkatchuk E, Burtscher M, Bernardi L Journal of Hypertension 
Eng Adaptation to intermittent hypoxia-hyperoxia as cardio-protective technology in patients with coronary artery disease 2012 Glazachev O, Pozdnyakov Y, Urinskiy A, Platonenko A, Spirina G oral presentation 
Eng Lipid Peroxidation and Antioxidant Enzyme Activity in Response to Interval Hypoxic Training 2002 El’chaninova SA, Smagina IV, Korenyak NA, Varshavskii B Ya  
Eng Effects of simulated altitude (normobaric hypoxia) on cardiorespiratory parameters and circulating endothelial precursors in healthy subjects 2007 Ciulla MM, Cortiana M, Silvestris I, Matteucci E, Ridolfi E, Giofrè F, Zanardelli M, Paliotti R, Cortelezzi A, Pierini A, Magrini F, Desiderio MA Respiratory Research 
Eng Intermittent hypoxia increases exercise tolerance in elderly men with and without coronary artery disease 2004 Burtscher M, Pachinger O, Erenburg I, Mitterbauer G, Faulhaber M, Puhringer R, Tkatchuk E International Journal of Cardiology 
Eng Effects of interval hypoxia on exercise tolerance: special focus on patients with CAD or COPD 2009 Burtscher M, Gatterer H, Szubski C, Pierantozzi E, Faulhaber M Sleep Breath19688232
Eng Intermittent hypoxia increases exercise tolerance in patients at risk for or with mild COPD 2008 Burtscher M, Haider T, Domej W, Linser T, Gatterer H, Faulhaber M, Pocecco E, Erenburg I, Tkatchuk E, Koch R, Bernardi L Respiratory Physiology & Neurobiology 
Eng Respiratory and cardiovascular adaptations to progressive hypoxia 2001 Bernardi L, Passino C, Serebrovskaya Z, Serebrovskaya T, Appenzeller O Eur Heart 
Eng Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia 2005 Foster GE, McKenzie DC, Milsom WK, Sheel AW J Physiol15975977
Eng Effects of Intermittent Hypoxia Training on Exercise Performance, Hemodynamics, and Ventilation in Healthy Senior Men 2008 Shatilo V, Korkushko O, Ischuk V, Downey H, Serebrovskaya T High Altitude Medicine & Biology