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Intermittent Hypoxia Mobilizes Hematopoietic Progenitors and Augments Cellular and Humoral Elements of Innate Immunity in Adult Men
The study tested the hypothesis that intermittent hypoxia treatment (IHT) modulates circulating hematopoietic stem and progenitor cells (HSPC) and augments humoral and cellular components of innate immunity in young, healthy men. Ten subjects (group 1: age 31–4 yr) were studied before and at 1 and 7 days after a 14-day IHT program consisting of four 5-min bouts/day of breathing 10% O2, lowering arterial O2 saturation to 84% to 85%, with intervening 5-min room-air exposures. Five more subjects (group 2: age 29–5 yr) were studied during 1 IHT session. Immunofluorescence detected HSPCs as CD45+ CD34+ cells in peripheral blood. Phagocytic and bactericidal activities of neutrophils, circulating immunoglobulins (IgM, IgG, IgA), immune complexes, complement, and cytokines (erythropoietin, TNF-a, IL-4, IFN-c) were measured. In group 1, the HSPC count fell 27% below pre-IHT baseline 1 week after completing IHT, without altering erythrocyte and reticulocyte counts.
Serebrovskaya T, Nikolskiy I, Nikolskaya V, Mallet RT, Ischuk V
Source: High Altitude Medicine & Biology