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Adaptation to intermittent hypoxia-hyperoxia as cardio-protective technology in patients with coronary artery disease
Adaptation to intermittent hypoxia (IHT) has been demonstrated to be effective in rehabilitation of patients with CAD, hypertension, mild COPD. We have proposed a new mode of IHT, with repeated episodes of hypoxia (10-12% O2 inhaled via face mask) interspersed with hyperoxic gas mixture (30-35% O2), instead of normoxic periods as in “traditional” IHT. In experimental studies, adaptation to hypoxia-hyperoxia has been evidenced to evoke more pronounced cardio-protective effects due to the higher intensity of redox-signalling without hypoxia deepening than hypoxia-normoxia (Arkhipenko Yu.V., Sazontova T.G., 2008), that increased physical endurance, preventing excessive ROS production in rat myocardium in tests with extreme physical loads.
Glazachev O, Pozdnyakov Y, Urinskiy A, Platonenko A, Spirina G
Source: oral presentation